Propandrol (Testosterone P) 1 vial/10 ml (100 mg/1 ml)

Propandrol (Testosterone Propionate) by Balkan Pharmaceuticals, an ester of the male sex hormone testosterone, is available in a convenient 10 ml bottle with a half-life of about 48 hours. Thus, this is its fastest oil ester, faster than which is only a suspension of testosterone (this is the form in which testosterone is found in our body).

Testosterone propionate begins its action immediately after injection and lasts for 24 hours. In the blood, almost 98% of testosterone binds to a specific fraction of globulins that bind testosterone and estradiol. Biotransformation occurs in the liver to various 17-ketosteroids, which, after conjugation with glucuronic or sulfuric acid, are excreted in the urine (approximately 90%). About 6% of the absorbed drug is excreted in the feces in an unbound form.

Steroid Profile of Testosterone Propionate

• anabolic activity - 100% of testosterone;
• androgenic activity - 100% of testosterone (high);
• aromatization (conversion to estrogens) - high (there is a need for antiestrogen);
• suppression of the axis of the hypothalamus-pituitary-testicles - expressed;
• toxicity to the liver - absent;
• method of administration - injections;
• duration of action - 2-3 days;
• elimination half-life and mrt (in / m) - 0.8 days and 1.5 days, respectively;
• the peak activity of propionate falls on the day of injection and gradually decreases within 24-36 hours after the injection;
• detection time - 40-60 days.

Effects of Testosterone Propionate

1. Increased Muscle Mass: Testosterone propionate can help increase protein and nitrogen synthesis in the body, which can lead to increased muscle mass with an appropriate training regimen and diet.
2. Improving Endurance and Strength: Taking testosterone propionate can increase erythropoiesis (formation of red blood cells) and improve muscle oxygen uptake. This can help improve endurance and increase strength during training.
3. improved recovery: Testosterone propionate can speed up the recovery process after intense training or injury. This can help athletes recover faster and train with more intensity.
4. increased bone density: Testosterone plays an important role in maintaining healthy bone density. Taking testosterone propionate can help strengthen bones and reduce the risk of osteoporosis.
5. increased libido: Testosterone is the main male sex hormone, and its level is associated with sexual function. Taking testosterone propionate can increase libido and improve sexual performance.

Application and dosage of Testosterone Propionate

Since this is a short-acting drug, injections should be given once every two days. In this case, a single dose is in the range of 50-200 mg (beginners: 50 mg / day, amateurs: 100 mg / day, professionals: 100-200 mg / day). Although propinate does not aromatize as actively as long-acting testosterone-containing AAS, it is worth introducing an aromatase inhibitor into the cycle.

Combined course

Most often, this drug is used by bodybuilders during the drying period. Thus, the following drugs are the best choice for a combined course: Nandrolone Phenylpropionate, Turinabol, Primobolan, Trenbolone Acetate, Oxandrolone, Drostanolone, Stanozolol, Winstrol.

Also, experienced athletes often introduce Propionate as part of a powerful mass gain course. They start taking it immediately after stopping the main AAS and use it within 2 weeks. Thanks to this, it is possible to minimize the effect of recoil and prepare the body for rehabilitation therapy.

An example cycle for beginner bodybuilders for cutting based on propionate:

• Propionate 50 mg every other day;
• Winstrol 30mg daily, starting at 10mg and working up to optimal over 1 week;
• after 6 weeks, anabolic agents should be canceled and after 3-4 days, PCT should be started.

Medical indications for taking Testosterone Propionate

In men – androgen deficiency after castration, eunuchoidism, impotence of hormonal origin, symptoms of male menopause (decreased libido, mental and physical activity), with acromegaly; with prostatic hypertrophy; osteoporosis caused by androgen deficiency; with angioedema forms of angina pectoris.

Among women – with menopausal vascular and nervous disorders in cases where estrogenic drugs are contraindicated (with tumors of the genital organs and mammary glands, uterine bleeding); simultaneously with radiation therapy for breast and ovarian cancer (usually in women under the age of 60); with dysfunctional uterine bleeding in elderly women.

Pharmacokinetic properties of Testosterone Propionate

Intramuscularly, deep into the gluteal muscle. The dose is set individually depending on the indications and the patient's response.

Men with eunuchoidism, congenital underdevelopment of the sex glands, their removal by surgery or as a result of trauma, as well as with acromegaly, are prescribed 25 mg daily or 50 mg every other day or 2 days later. The duration of treatment depends on the effectiveness of therapy and the nature of the disease. Usually treatment is carried out for a long time. After the improvement of the clinical picture, testosterone propionate is administered in maintenance doses: 5-10 mg daily or every other day.

With impotence due to functional insufficiency of the gonads, overwork and nervous exhaustion, as well as with male menopausal syndrome, 10 mg daily or 25 mg 2-3 times a week for 1-2 months are prescribed.

With prostatic hypertrophy in the initial stage, take 10 mg every other day for 1-2 months.

In patients with angina pectoris, a positive effect is sometimes observed when testosterone is used at 10–12.5 mg once a week; with good tolerance, the number of injections is increased to two per week (for 3 to 5 weeks). By the end of treatment, the dose and number of injections are again reduced. The course of treatment consists of 15-20 injections.

Women over 45 with dysfunctional uterine bleeding are prescribed 10-25 mg every other day for 20-30 days until bleeding stops and atrophic cells appear in vaginal smears. Preliminary it is necessary to exclude malignant neoplasms of the uterus.

With vascular and nervous disorders of menopausal origin in women and the presence of contraindications to the use of estrogens, testosterone propionate is administered at 10 mg every other day or 25 mg 2 times a week for 2-3 weeks.

In malignant tumors of the breast or ovaries, testosterone propionate is administered at a dose of 50 mg daily for several months, then (depending on the results of treatment) the dose is reduced and maintenance doses are prescribed for a long time. As an addition to surgery or radiation therapy, the drug is prescribed for women under 60 years of age (older women are recommended to take estrogens).

Higher intramuscular doses for adults: single 50 mg, daily 100 mg.

The drug must not be administered intravenously!

Side effects

• priapism and other signs of excessive sexual stimulation (frequent erections);
• in boys in the prepubertal period - accelerated sexual development, increased frequency of erections, enlargement of the penis and premature closure of the epiphyses;
• damage to spermatogenesis and impaired maturation of spermatozoa, oligospermia and a decrease in ejaculate volume;
• anomalies of the prostate;
• in women - bleeding from the birth canal, increased libido; with prolonged use of the drug, symptoms of virilization are possible;
• hirsutism, gynecomastia;
• seborrhea, acne, oily skin, accelerated hair loss;
• sodium and water retention, edema;
• symptoms of hypercalcemia;
• thrombophlebitis;
• nausea, cholestatic jaundice, increased levels of liver aminotransferases (as they stop taking, they normalize);
• headache, depression, aggressiveness, anxiety, sleep disturbance, paresthesia.
• possible pain, itching and hyperemia at the injection site.

Contraindications

Increased individual sensitivity to the components of the drug, carcinoma of the prostate or breast; nephrosis or nephrotic phase of nephritis, edema; hypercalcemia; liver dysfunction; diabetes; heart and coronary insufficiency, a history of myocardial infarction, atherosclerosis in elderly men; pregnancy, breastfeeding.

Overdose

In acute overdose, testosterone toxicity is extremely low.

In chronic overdose, priapism may develop. In this case, treatment should be stopped, and after the disappearance of symptoms - start in smaller doses.

Precautions and application features

In the event of androgen-dependent adverse reactions, testosterone treatment should be discontinued. After the disappearance of side effects, resume treatment at lower doses.

Patients with latent or severe heart failure, impaired renal function, hypertension, epilepsy or migraine (or a history of these conditions) should be monitored constantly, since androgens can in some cases cause sodium and water retention. With prolonged use, check liver function. In patients with breast cancer, hypernephroma, lung cancer with bone metastases, check the level of calcium in the blood and urine.

In prepubertal boys, androgens should be used with caution to avoid premature closure of the epiphyses and accelerated sexual development.

What other drugs will affect Testosterone Propionate

• Antiestrogens: Testosterone can undergo a process of aromatization in which some of the testosterone is converted to estrogen. Drugs such as aromatase inhibitors (such as anazastrozole or letrozole) can help lower estrogen levels in the body and reduce the risk of unwanted estrogen-related side effects such as gynecomastia (enlargement of the breasts in men);
• Liver Protective Drugs: Some anabolic steroids, including testosterone propionate, can have adverse effects on the liver. Therefore, the use of liver protective drugs, such as silymarin (mariana black cumin) or tudka, can help reduce the negative effects on the liver;
• Blood pressure medications: Muscle gain and the use of anabolic steroids can increase blood pressure in some people. In such cases, blood pressure medications such as ACE (Angiotensin Converting Enzyme) inhibitors or beta-blockers may be recommended to help maintain healthy blood pressure.

Storage conditions

Store at a temperature of 15-25 ° C, in a dry, dark place and out of the reach of children.

Best before date

5 years. Do not use after the expiry date stated on the package.

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