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Testosterone P 1 vial/10 ml (100 mg/1 ml)

Тестостерон Пропионат 1 флакон

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Short description

Testosterona P (testosterone propionate) from Balkan Pharma is an ester of the male sex hormone testosterone, available in a convenient 10 ml bottle with a half-life of about 48 hours. Thus, this is its fastest oil ester, faster than which is only a suspension of testosterone (it is in this form that testosterone is in our body). Testosterone P begins to act almost immediately, a high concentration of the drug remains for 24-48 hours.

Testosterone propionate begins its action immediately after injection and acts within 24 hours. In the blood, almost 98% of testosterone binds to a specific fraction of globulins that binds testosterone and estradiol. Biotransformation occurs in the liver to various 17-ketosteroids, which, after conjugation with glucuronic or sulfuric acid, are excreted in the urine (approximately 90%). About 6% of the absorbed drug is excreted unbound in the feces.

Indications

In men - androgenic insufficiency after castration, eunuchoidism, impotence of hormonal origin, symptoms of male menopause (decreased libido, mental and physical activity), with acromegaly; with prostatic hypertrophy; osteoporosis caused by androgen deficiency; with angioneurotic forms of angina pectoris.

In women - with climacteric vascular and nervous disorders in cases where estrogen drugs are contraindicated (for tumors of the genitals and mammary glands, uterine bleeding); concurrently with radiation therapy for breast and ovarian cancer (usually in women under the age of 60); with dysfunctional uterine bleeding in older women.

Pharmacokinetic properties of Testosterone Propionate

Intramuscularly, deep into the gluteus muscle. The dose is set individually, depending on the indications and the patient's response.

Men with eunuchoidism, congenital underdevelopment of the gonads, their removal by surgery or as a result of injury, as well as with acromegaly, are prescribed 25 mg daily or 50 mg every other day or after 2 days. The duration of treatment depends on the effectiveness of therapy and the nature of the disease. Usually, the treatment is carried out for a long time. After improving the clinical picture, testosterone propionate is administered in maintenance doses: 5-10 mg daily or every other day.

With impotence due to functional insufficiency of the gonads, overwork and nervous exhaustion, as well as with male climacteric syndrome, appoint 10 mg daily or 25 mg 2-3 times a week for 1-2 months.

With hypertrophy of the prostate in the initial stage, take 10 mg every other day for 1-2 months.

In patients with angina pectoris, a positive effect is sometimes observed when testosterone is used at 10-12.5 mg once a week; with good tolerance, the number of injections is increased to two per week (within 3 - 5 weeks). By the end of treatment, the dose and the number of injections are reduced again. The course of treatment consists of 15-20 injections.

Women over 45 years of age with dysfunctional uterine bleeding are prescribed 10-25 mg every other day for 20-30 days until the bleeding stops and atrophic cells appear in vaginal smears. Previously, malignant neoplasms of the uterus should be excluded.

In case of vascular and nervous disorders of climacteric origin in women and the presence of contraindications to the use of estrogens, testosterone propionate is administered 10 mg every other day or 25 mg 2 times a week for 2-3 weeks.

In malignant tumors of the breast or ovaries, testosterone propionate is administered at a dose of 50 mg daily for several months, then (depending on the results of treatment) the dose is reduced and maintenance doses are prescribed for a long time. As an adjunct to surgery or radiation therapy, the drug is prescribed for women under 60 years of age (older women are advised to take estrogens).

Higher doses intramuscularly for adults: single 50 mg, daily 100 mg.

The drug should not be administered intravenously!

Side effects

  • Priapism and other signs of excessive sexual stimulation (frequent erections);
  • in boys in the prepubertal period - accelerated sexual development, increased frequency of erections, enlarged penis and premature closure of the epiphyses;
  • damage to spermatogenesis and impaired sperm maturation, oligospermia and a decrease in ejaculate volume;
  • anomalies of the prostate gland;
  • in women - bleeding from the birth canal, increased libido; with prolonged use of the drug, symptoms of virilization are possible;
  • hirsutism, gynecomastia;
  • seborrhea, acne, oily skin, accelerated hair loss;
  • sodium and water retention, edema;
  • symptoms of hypercalcemia;
  • thrombophlebitis;
  • nausea, cholestatic jaundice, increased levels of liver aminotransferases (as the intake is discontinued, they normalize);
  • headache, depression, aggressiveness, anxiety, sleep disturbance, paresthesia.
  • Pain, itching and redness at the injection site are possible.

Contraindications

increased individual sensitivity to the components of the drug, prostate or breast carcinoma; nephrosis or nephrotic phase of nephritis, edema; hypercalcemia; impaired liver function; diabetes; heart and coronary insufficiency, history of myocardial infarction, atherosclerosis in elderly men; pregnancy, breastfeeding.

Overdose

In acute overdose, the toxicity of testosterone is extremely low.

With chronic overdose, priapism may develop. In this case, treatment should be discontinued, and after the disappearance of symptoms, start in lower doses.

Precautions and application features

In the event of androgen-dependent adverse reactions, testosterone treatment should be discontinued. After the side effects disappear, resume treatment at lower doses.

Patients with latent or severe heart failure, impaired renal function, hypertension, epilepsy, or migraine (or a history of these conditions) should be monitored continuously, since androgens can in some cases cause sodium and water retention. With prolonged use, check liver function. In patients with breast cancer, hypernephroma, lung cancer with bone metastases, check the level of calcium in the blood and urine.

In prepubertal boys, androgens should be used with caution to avoid premature epiphyseal closure and accelerated sexual development.

Interaction with other medications

Increases the effectiveness of anticoagulants and hypoglycemic agents (it is necessary to change the dose), inhibits the excretion of cyclosporine. Liver enzyme inducers (barbiturates, rifampicin, carbamazepine, phenylbutazone, phenytoin) reduce the effect of testosterone.

Storage conditions

Store at a temperature of 15-25 ° C, in a dry, dark place and out of reach of children.

Shelf life

5 years. Do not use after the expiration date printed on the package.

Characteristics

Active ingridient
Testosterone Propionate

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Testosterone P 1 vial/10 ml (100 mg/1 ml)

Тестостерон Пропионат 1 флакон

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