Tamoxifen 100 tabs (10 mg/1 tab)

Tamoxifen is a drug that is commonly used in medicine to treat breast cancer in women and to prevent breast cancer in women at high risk of developing this tumor.

Effects of taking Tamoxifen

Athletes take it to prevent the manifestation of side effects such as gynecomastia, fluid accumulation and female-type fat deposition. With proper administration of the drug, the following effects are observed:

1. estrogen receptors are blocked;
2. the level of endogenous testosterone is restored;
3. the concentration of cholesterol is normalized - due to an increase in the number of lipoproteins;
4. the accumulation of fluid in the tissues is minimized;
5. potency is restored.

At the end of the Tamoxifen course, the level of the male hormone in the blood is 80% of the norm.

How Tamoxifen works

Tamoxifen is not an anabolic steroid, but a selective estrogen receptor modulator (SERM). It binds to estrogen receptors in tissues that normally respond to estrogen, such as the mammary glands, and blocks their action.

Application and dosage of Tamoxifen

Some bodybuilders start taking the drug while still on the course of anabolic steroids. In this option, the effectiveness of the drug will be obvious - undesirable effects caused by an increase in the content of estrogens in the bloodstream of athletes will be prevented. The optimal allowable dosage of the drug per day varies 10-20 mg, connecting it to the 2nd week of the course. It should be borne in mind that this scheme can harm the action of the main anabolic.

If you use antiestrogen only for the purpose of post-course PCT, then it is best to choose a dose of 20-40 mg and use it for 30-45 days. If the course of AAS is extremely heavy, then the dose can be increased even up to 80 mg per day. In this case, it is worth connecting hepatoprotectors.

Despite the fact that the hormone is considered a potent antiestrogen, it does not prevent the activity of estrogen, but only blocks it.

Side effects

• headache, nausea, vomiting, diarrhea and fatigue;
• sudden hot flashes;
• loss of appetite and weight;
• a decrease in the number of platelets, which can lead to an increased risk of bleeding;
• increased risk of thrombosis, including deep vein thrombosis and pulmonary embolism;
• increased risk of developing endometrial cancer;
• increased risk of developing cataracts.

If you experience any of these side effects, you should contact your specialist. In some cases, your doctor may lower your tamoxifen dose or prescribe another medicine that can help manage the side effects.

What to Avoid

• Pregnancy. Tamoxifen may harm the developing fetus1. Therefore, premenopausal women should carefully check the absence of pregnancy before starting treatment and use reliable methods of contraception during treatment;
• Hypersensitivity. Tamoxifen may cause allergic reactions in people with hypersensitivity to its components1. Therefore, before starting treatment, it is necessary to clarify the presence of an allergy to tamoxifen or other drugs;
• Anastrozole. Tamoxifen is not compatible with anastrozole, another drug for the treatment of breast cancer1. Therefore, the simultaneous use of these drugs may reduce their effectiveness or increase the risk of side effects;
• Infertility treatment. Tamoxifen is not intended for the treatment of infertility and may have a negative effect on reproductive function. Therefore, it should not be used to stimulate ovulation or increase fertility;
• Contact with body fluids. Tamoxifen may be excreted in urine, feces or vomit and pose a danger to people around. Therefore, when taking tamoxifen, it is necessary to observe hygiene measures and avoid contact with these fluids.

What other drugs will affect Tamoxifen

It may interact with other medicines that affect hormones or the immune system. For example:

• Anticoagulants (such as warfarin) may increase the risk of bleeding when used with tamoxifen;
• Antidepressants (such as fluoxetine or paroxetine) may reduce the effectiveness of tamoxifen because they block the enzyme that helps activate it;
• Immunosuppressive drugs (such as cyclosporine or tacrolimus) may increase the blood concentration of tamoxifen and increase its side effects.

It may interact with other steroid medications that also affect hormonal balance:

• Anabolic steroids (such as testosterone or nandrolone) may reduce the effect of tamoxifen and increase the risk of developing prostate cancer;
• Corticosteroids (such as prednisone or dexamethasone) may increase the blood concentration of tamoxifen and increase its side effects;
• Contraceptive steroids (such as estradiol or norethisterone) may reduce the effectiveness of tamoxifen and increase the risk of thrombosis.

This is not a complete list of drugs that can affect Tamoxifen.

Origin of the drug

Tamoxifen is a drug that was developed in the 1960s by British chemists Arthur Walton and Dora Richardson. They were looking for a treatment for breast cancer that would block the action of estrogens on tumor cells. Tamoxifen was the first of a class of drugs called selective estrogen receptor modulators (SERMs)1. It was approved for clinical use in 1977 and has since become one of the most widely used anticancer drugs in the world.